The Past, Present, and Future of Embryo Selection in In Vitro Fertilization
نویسنده
چکیده
Assisted reproductive technology (ART) has been recognized for its success in treating infertility, a condition that affects 15 percent of couples in the United States. The most popular option is in vitro fertilization (IVF), which relies on embryo culture, selection, and transfer for implantation, with the ultimate aim of pregnancy. Previous embryo selection methods relied on morphological factors to select for greatest viability. At Yale's Frontiers in Reproduction Conference on April 29, 2011, at the New Haven Lawn Club, Dr. Denny Sakkas of Yale's Department of Obstetrics, Gynecology, and Reproductive Sciences presented a paradigm shift: using morphological factors along with metabolic, protein, and genetic markers in culture media to enhance embryo selection and IVF success rates.
منابع مشابه
P-31: Evaluation of In vitro Fertilization Rate, Embryo Quality and Development in Experimental Model of Diabetes induced by STZ: in Female Mouse
Background: Diabetes mellitus is a metabolic condition characterized by elevated blood glucose levels secondary to absolute impairment of insulin secretion. Maternal diabetes has been demonstrated to adversely affect pre implantation embryo development and pregnancy outcomes. Emerging evidence has implicated that these effects are associated with compromised oocyte competence. Several developme...
متن کاملI-11: The Use of Oxygen Consumption for Oocyte and Embryo Selection
Assisted human reproduction is characterized by a high variability in results regarding pregnancy and birth rates. In fact, in a cohort of fertilized oocytes from the same stimulation cycle, the development rate varies drastically, even though produced at the same time and under similar conditions. This variability results in large differences in implantation potential of human embryos develope...
متن کاملEvaluation of the protective effect of Satureja khozestanica essential oil on in vitro fertilization potential and embryo development in oxidative stress induced by Nonylphenol
Background & aim: Nonylphenol (NP) has been known as an immunosuppressant agent, and reported to induce oxidative stress, to impact gonadal cells nucleus and to reduce the fertilizing potential. Therefore, present study was aimed to evaluate the protective effect of Satureja Khuzestanica, as a potential antioxidant, on in vitro fertilized embryos development following exposure to NP. Methods: ...
متن کاملP-25: Study of the Effect of Experimental Diabetes Induced by STZ on In vitro Fertilization and Preimplantation Embryo Development Rate in Male Mouse Model
Background: Diabetes is a metabolic disease caused by a deficiency in the pancreatic secretion of insulin and/or by the inability of tissues to efficiently respond to insulin, events that cause hyperglycemia and affect all organs.Tissue alterations caused by diabetes affect different organic systems , including the male reproductive system. Reproductive dysfunction is one of the common secondar...
متن کاملP-91: The Effects of Mesenchymal StemCell- Conditioned Medium on The Fertilization Rate and Embryo Development inNMRI Mice
Background: Normal growth of oocytes, embryos and also successful implantation depend on environmental factors such as the secretion of cumulus cells and composition of follicular and tubular fluids. Therefore, addition of serum, conditioned medium (CM) to the culture medium and also co-culture with somatic cells improve mammalian embryo development. So, in the respect to the secretion of diffe...
متن کاملResurgence of Minimal Stimulation In Vitro Fertilization with A Protocol Consisting of Gonadotropin Releasing Hormone-Agonist Trigger and Vitrified-Thawed Embryo Transfer
Minimal stimulation in vitro fertilization (mini-IVF) consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are report...
متن کامل